First started in 2013 from a grant from the University of Mississippi and the support of the Oxford Park Commission, Run Oxford's first Board of Directors included Marvin King (President), Jill Knight (Vice-President), Nathan Hammer (Secretary), and Ed Dean (Treasurer).
In June 2015, Run Oxford produced its first race, the Splash ‘n Dash 5k. It was a free run benefitting More Than A Meal. Run Oxford also held the Mighty Half and 5k presented by Rebel Well | Blue Cross & Blue Shield of Mississippi Foundation on February 20, 2016. Over 500 runners participated and this event served to bring back a half marathon to Oxford, MS. Over 800 runners participated in the first annual Great 38 in October 2016 and this year's races promise to give every type of runner a fun and challenging time.